Nature Communications (Dec 2020)

Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling

  • Francesco De Virgiliis,
  • Thomas H. Hutson,
  • Ilaria Palmisano,
  • Sarah Amachree,
  • Jian Miao,
  • Luming Zhou,
  • Rositsa Todorova,
  • Richard Thompson,
  • Matt C. Danzi,
  • Vance P. Lemmon,
  • John L. Bixby,
  • Ilka Wittig,
  • Ajay M. Shah,
  • Simone Di Giovanni

DOI
https://doi.org/10.1038/s41467-020-20179-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Pre conditioning injury or environmental enrichment have been shown to promote axon regeneration. Here the authors show that environmental enrichment, combined with preconditioning injury promotes regeneration via a redox signalling dependent mechanism.