mBio
(Jun 2021)
Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression
Wonyong Kim,
Rundong Liu,
Sunmin Woo,
Kyo Bin Kang,
Hyun Park,
Young Hyun Yu,
Hyung-Ho Ha,
Seung-Yoon Oh,
Ji Ho Yang,
Hangun Kim,
Sung-Hwan Yun,
Jae-Seoun Hur
Affiliations
Wonyong Kim
ORCiD Korean Lichen Research Institute, Sunchon National University, Suncheon, South Korea<?A3B2 show [zaq no="AQGRid1"]?>
Rundong Liu
Korean Lichen Research Institute, Sunchon National University, Suncheon, South Korea<?A3B2 show [zaq no="AQGRid1"]?>
Sunmin Woo
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul, South Korea
Kyo Bin Kang
ORCiD Research Institute of Pharmaceutical Sciences, College of Pharmacy, Sookmyung Women's University, Seoul, South Korea
Hyun Park
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Young Hyun Yu
College of Pharmacy, Sunchon National University, Suncheon, South Korea
Hyung-Ho Ha
College of Pharmacy, Sunchon National University, Suncheon, South Korea
Seung-Yoon Oh
Department of Biology and Chemistry, Changwon National University, Changwon, South Korea
Ji Ho Yang
Korean Lichen Research Institute, Sunchon National University, Suncheon, South Korea<?A3B2 show [zaq no="AQGRid1"]?>
Hangun Kim
College of Pharmacy, Sunchon National University, Suncheon, South Korea
Sung-Hwan Yun
Department of Medical Sciences, Soonchunhyang University, Asan, South Korea
Jae-Seoun Hur
ORCiD Korean Lichen Research Institute, Sunchon National University, Suncheon, South Korea<?A3B2 show [zaq no="AQGRid1"]?>
DOI
https://doi.org/10.1128/mBio.01111-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Lichens play significant roles in ecosystem function and comprise about 20% of all known fungi. Polyketide-derived natural products accumulate in the cortical and medullary layers of lichen thalli, some of which play key roles in protection from biotic and abiotic stresses (e.g., herbivore attacks and UV irradiation).
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