Journal of Virus Eradication (Oct 2016)
Impact of orphan status on HIV treatment outcomes and retention in care of children and adolescents in Asia
- B.u.i.V.u. Huy,
- S.i.r.i.n.y.a. Teeraananchai,
- L.e.N.g.o.c. Oanh,
- J.o.h.n. Tucker,
- N.i.a. Kurniati,
- R.a.w.i.w.a.n. Hansudewechakul,
- K.h.a.n.h.H.u.u. Truong,
- V.o.h.i.t.h. Khol,
- L.a.m. Van Nguyen,
- V.i.e.t. Chau Do,
- P.a.g.a.k.r.o.n.g. Lumbiganon,
- N.a.n.t.a.k.a. Kongstan,
- T.o.r.s.a.k. Bunupuradah,
- T.a.v.i.t.i.y.a. Sudjaritruk,
- N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy,
- N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff,
- K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali,
- D.e.w.i.K.u.m.a.r.a. Wati,
- M.o.y.S.i.e.w. Fong,
- R.e.v.a.t.h.y. Nallusamy,
- A.z.a.r. Kariminia,
- A.n.n.e.t.t.e.H. Sohn
Affiliations
- B.u.i.V.u. Huy
- Hanoi Medical University, Hanoi, Vietnam
- S.i.r.i.n.y.a. Teeraananchai
- HIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
- L.e.N.g.o.c. Oanh
- Worldwide Orphans Foundation, Ho Chi Minh City, Vietnam
- J.o.h.n. Tucker
- New Hope for Cambodian Children, Phnom Penh, Cambodia
- N.i.a. Kurniati
- Cipto Mangunkusumo – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia
- R.a.w.i.w.a.n. Hansudewechakul
- Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand
- K.h.a.n.h.H.u.u. Truong
- Children's Hospital 1, Ho Chi Minh City, Vietnam
- V.o.h.i.t.h. Khol
- National Centre for HIV/AIDS Dermatology and STDs and University of Health Sciences, Phnom Penh, Cambodia
- L.a.m. Van Nguyen
- National Hospital of Pediatrics, Hanoi, Vietnam
- V.i.e.t. Chau Do
- Children's Hospital 2, Ho Chi Minh City, Vietnam
- P.a.g.a.k.r.o.n.g. Lumbiganon
- Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
- N.a.n.t.a.k.a. Kongstan
- Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
- T.o.r.s.a.k. Bunupuradah
- HIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
- T.a.v.i.t.i.y.a. Sudjaritruk
- Department of Pediatrics, Faculty of Medicine, Chiang Mai University and Research Institute for Health Sciences, Chiang Mai, Thailand
- N.a.g.a.l.i.n.g.e.s.w.a.r.a.n. Kumarasamy
- YRGCARE Medical Centre, CART CRS, Chennai, India
- N.i.k.K.h.a.i.r.u.l.d.d.i.n.N.i.k. Yusoff
- Hospital Raja Perempuan Zainab II, Kelantan, Malaysia
- K.a.m.a.r.u.l.A.z.a.h.a.r. Mohd Razali
- Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia
- D.e.w.i.K.u.m.a.r.a. Wati
- Sanglah Hospital, Udayana University, Bali, Indonesia
- M.o.y.S.i.e.w. Fong
- Hospital Likas, Kota Kinabalu, Malaysia
- R.e.v.a.t.h.y. Nallusamy
- Penang Hospital, Penang, Malaysia
- A.z.a.r. Kariminia
- The Kirby Institute, UNSW Australia, Sydney, Australia
- A.n.n.e.t.t.e.H. Sohn
- TREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, Thailand; Corresponding author: Annette H Sohn, TREAT Asia/amfAR, 388 Sukhumvit Road, 2104 Klongtoey, Bangkok, 10110, Thailand
- DOI
- https://doi.org/10.1016/s2055-6640(20)30875-x
- Journal volume & issue
-
Vol. 2,
no. 4
pp. 227 – 231
Abstract
An analysis of the impact of orphanhood at antiretroviral therapy (ART) initiation on HIV outcomes in Asia included 4300 children; 51% were male. At ART initiation, 1805 (42%) were non-orphans (median age: 3 years), 1437 (33%) were single orphans (6 years) and 1058 (25%) were double orphans (7 years). Ten-year post-ART survival was 93.4–95.2% across orphan categories. Clinic transfers were higher among single and double orphans than non-orphans (41% vs 11%, P<0.001). On multivariate analysis, children ≥3 years at ART initiation (hazard ratio 1.58 vs <3 years, 95% confidence interval: 1.11–2.24) were more likely to be lost to follow-up. Although post-ART mortality and retention did not differ by orphan status, orphans were at greater risk of starting ART at older ages, and with more severe immunosuppression and poorer growth.
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