Analysis of bone mineral density and relevant factors in patients with type 1 diabetes

Abstract

We investigated changes in bone mineral density (BMD) and relevant factors of BMD in patients with type 1 diabetes (T1D). A total of 47 patients with T1D and 40 healthy controls participated in this study. The waist-to-hip ratio (WHR) and body mass index (BMI) were calculated after physical examination. The lumbar spine (L2-L4) BMD and left femoral neck BMD were examined. Blood samples were collected. The BMI, WHR, fasting C peptide (FCP), postprandial C peptide (2hCP), lumbar spine and left femoral neck BMD of the patients with T1D were significantly lower than those of healthy controls, while the fasting plasma glucose (FPG), postprandial plasma glucose (2hPG) and hemoglobin A1c (HbA1c) were higher (P <0.05). Duration of T1D and HbA1c were negatively correlated with lumbar spine and left femoral neck BMD. The FCP and 2hCP were positively correlated with lumbar spine and left femoral neck BMD.

Keywords

• bone mineral density
• body mass index
• type 1 diabetes