Microbiota alters the metabolome in an age- and sex- dependent manner in mice

Kirsty Brown; Carolyn A. Thomson; Soren Wacker; Marija Drikic; Ryan Groves; Vina Fan; Ian A. Lewis; Kathy D. McCoy

doi:10.1038/s41467-023-37055-1

Nature Communications (Mar 2023)

Microbiota alters the metabolome in an age- and sex- dependent manner in mice

Kirsty Brown,
Carolyn A. Thomson,
Soren Wacker,
Marija Drikic,
Ryan Groves,
Vina Fan,
Ian A. Lewis,
Kathy D. McCoy

Affiliations

Kirsty Brown: Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary
Carolyn A. Thomson: Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary
Soren Wacker: Department of Biological Sciences, University of Calgary
Marija Drikic: Department of Biological Sciences, University of Calgary
Ryan Groves: Department of Biological Sciences, University of Calgary
Vina Fan: Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary
Ian A. Lewis: Department of Biological Sciences, University of Calgary
Kathy D. McCoy: Department of Physiology and Pharmacology, Snyder Institute of Chronic Diseases, Cumming School of Medicine, University of Calgary

DOI: https://doi.org/10.1038/s41467-023-37055-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Commensal microbes contribute considerably to mammalian metabolism. Here the authors report the relative contributions of microbiome, age and sex to metabolism throughout the body and uncover age- and sex- specificity in how microbes affect metabolite levels in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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