Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Yoshiharu Muto; Parker C. Wilson; Nicolas Ledru; Haojia Wu; Henrik Dimke; Sushrut S. Waikar; Benjamin D. Humphreys

doi:10.1038/s41467-021-22368-w

Nature Communications (Apr 2021)

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Yoshiharu Muto,
Parker C. Wilson,
Nicolas Ledru,
Haojia Wu,
Henrik Dimke,
Sushrut S. Waikar,
Benjamin D. Humphreys

Affiliations

Yoshiharu Muto: Division of Nephrology, Department of Medicine, Washington University in St. Louis
Parker C. Wilson: Department of Pathology and Immunology, Washington University in St. Louis
Nicolas Ledru: Division of Nephrology, Department of Medicine, Washington University in St. Louis
Haojia Wu: Division of Nephrology, Department of Medicine, Washington University in St. Louis
Henrik Dimke: Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark
Sushrut S. Waikar: Section of Nephrology, Department of Medicine, Boston University School of Medicine and Boston Medical Center
Benjamin D. Humphreys: Division of Nephrology, Department of Medicine, Washington University in St. Louis

DOI: https://doi.org/10.1038/s41467-021-22368-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

Read online

Single cell transcriptomic and epigenomic sequencing of human kidney highlight diverse cell types and states. These findings help characterize a novel population of injured proximal tubule cells and illustrate the power of multi-omic approaches to characterizing human tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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