A neurotoxin that specifically targets Anopheles mosquitoes

Estefania Contreras; Geoffrey Masuyer; Nadia Qureshi; Swati Chawla; Harpal S. Dhillon; Han Lim Lee; Jianwu Chen; Pål Stenmark; Sarjeet S. Gill

doi:10.1038/s41467-019-10732-w

Nature Communications (Jun 2019)

A neurotoxin that specifically targets Anopheles mosquitoes

Estefania Contreras,
Geoffrey Masuyer,
Nadia Qureshi,
Swati Chawla,
Harpal S. Dhillon,
Han Lim Lee,
Jianwu Chen,
Pål Stenmark,
Sarjeet S. Gill

Affiliations

Estefania Contreras: Department of Molecular, Cell and Systems Biology, University of California
Geoffrey Masuyer: Department of Biochemistry and Biophysics, Stockholm University
Nadia Qureshi: Department of Molecular, Cell and Systems Biology, University of California
Swati Chawla: Department of Molecular, Cell and Systems Biology, University of California
Harpal S. Dhillon: Department of Molecular, Cell and Systems Biology, University of California
Han Lim Lee: Unit of Medical Entomology, Institute for Medical Research
Jianwu Chen: Department of Molecular, Cell and Systems Biology, University of California
Pål Stenmark: Department of Biochemistry and Biophysics, Stockholm University
Sarjeet S. Gill: Department of Molecular, Cell and Systems Biology, University of California

DOI: https://doi.org/10.1038/s41467-019-10732-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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So far identified clostridial neurotoxins target vertebrates. Here, Contreras et al. isolate the clostridial-like neurotoxin PMP1 from Paraclostridium bifermentans strains and show that it selectively targets anopheline mosquitoes by targeting mosquito syntaxin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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