Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

Jeannette Abplanalp; Mario Leutert; Emilie Frugier; Kathrin Nowak; Roxane Feurer; Jiro Kato; Hans V. A. Kistemaker; Dmitri V. Filippov; Joel Moss; Amedeo Caflisch; Michael O. Hottiger

doi:10.1038/s41467-017-02253-1

Nature Communications (Dec 2017)

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

Jeannette Abplanalp,
Mario Leutert,
Emilie Frugier,
Kathrin Nowak,
Roxane Feurer,
Jiro Kato,
Hans V. A. Kistemaker,
Dmitri V. Filippov,
Joel Moss,
Amedeo Caflisch,
Michael O. Hottiger

Affiliations

Jeannette Abplanalp: Department of Molecular Mechanisms of Disease, University of Zurich
Mario Leutert: Department of Molecular Mechanisms of Disease, University of Zurich
Emilie Frugier: Department of Biochemistry, University of Zurich
Kathrin Nowak: Department of Molecular Mechanisms of Disease, University of Zurich
Roxane Feurer: Department of Molecular Mechanisms of Disease, University of Zurich
Jiro Kato: Laboratory of Translational Research, National Heart, Lung and Blood Institute, NIH
Hans V. A. Kistemaker: Leiden Institute of Chemistry, Department of Bio-organic Synthesis, Leiden University
Dmitri V. Filippov: Leiden Institute of Chemistry, Department of Bio-organic Synthesis, Leiden University
Joel Moss: Laboratory of Translational Research, National Heart, Lung and Blood Institute, NIH
Amedeo Caflisch: Department of Biochemistry, University of Zurich
Michael O. Hottiger: Department of Molecular Mechanisms of Disease, University of Zurich

DOI: https://doi.org/10.1038/s41467-017-02253-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Protein ADP-ribosylation has emerged as a key post translational modification that regulates several stress responses. Here the authors characterize ARH3 as a major serine-specific mono–ADP-ribosylhydrolase and use a proteomics approach to identify the cellular targets of ARH3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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