Journal of Clinical Medicine (Nov 2019)
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
- Lorenzo Cavagna,
- Ernesto Trallero-Araguás,
- Federica Meloni,
- Ilaria Cavazzana,
- Jorge Rojas-Serrano,
- Eugen Feist,
- Giovanni Zanframundo,
- Valentina Morandi,
- Alain Meyer,
- Jose Antonio Pereira da Silva,
- Carlo Jorge Matos Costa,
- Oyvind Molberg,
- Helena Andersson,
- Veronica Codullo,
- Marta Mosca,
- Simone Barsotti,
- Rossella Neri,
- Carlo Scirè,
- Marcello Govoni,
- Federica Furini,
- Francisco Javier Lopez-Longo,
- Julia Martinez-Barrio,
- Udo Schneider,
- Hanns-Martin Lorenz,
- Andrea Doria,
- Anna Ghirardello,
- Norberto Ortego-Centeno,
- Marco Confalonieri,
- Paola Tomietto,
- Nicolò Pipitone,
- Ana Belen Rodriguez Cambron,
- María Ángeles Blázquez Cañamero,
- Reinhard Edmund Voll,
- Sarah Wendel,
- Salvatore Scarpato,
- Francois Maurier,
- Massimiliano Limonta,
- Paolo Colombelli,
- Margherita Giannini,
- Bernard Geny,
- Eugenio Arrigoni,
- Elena Bravi,
- Paola Migliorini,
- Alessandro Mathieu,
- Matteo Piga,
- Ulrich Drott,
- Christiane Delbrueck,
- Jutta Bauhammer,
- Giovanni Cagnotto,
- Carlo Vancheri,
- Gianluca Sambataro,
- Ellen De Langhe,
- Pier Paolo Sainaghi,
- Cristina Monti,
- Francesca Gigli Berzolari,
- Mariaeva Romano,
- Francesco Bonella,
- Christof Specker,
- Andreas Schwarting,
- Ignacio Villa Blanco,
- Carlo Selmi,
- Angela Ceribelli,
- Laura Nuno,
- Antonio Mera-Varela,
- Nair Perez Gomez,
- Enrico Fusaro,
- Simone Parisi,
- Luigi Sinigaglia,
- Nicoletta Del Papa,
- Maurizio Benucci,
- Marco Amedeo Cimmino,
- Valeria Riccieri,
- Fabrizio Conti,
- Gian Domenico Sebastiani,
- Annamaria Iuliano,
- Giacomo Emmi,
- Daniele Cammelli,
- Marco Sebastiani,
- Andreina Manfredi,
- Javier Bachiller-Corral,
- Walter Alberto Sifuentes Giraldo,
- Giuseppe Paolazzi,
- Lesley Ann Saketkoo,
- Roberto Giorgi,
- Fausto Salaffi,
- Jose Cifrian,
- Roberto Caporali,
- Francesco Locatelli,
- Enrico Marchioni,
- Alberto Pesci,
- Giulia Dei,
- Maria Rosa Pozzi,
- Lomater Claudia,
- Jorg Distler,
- Johannes Knitza,
- George Schett,
- Florenzo Iannone,
- Marco Fornaro,
- Franco Franceschini,
- Luca Quartuccio,
- Roberto Gerli,
- Elena Bartoloni,
- Silvia Bellando Randone,
- Giuseppe Zampogna,
- Montserrat I. Gonzalez Perez,
- Mayra Mejia,
- Esther Vicente,
- Konstantinos Triantafyllias,
- Raquel Lopez-Mejias,
- Marco Matucci-Cerinic,
- Albert Selva-O’Callaghan,
- Santos Castañeda,
- Carlomaurizio Montecucco,
- Miguel Angel Gonzalez-Gay
Affiliations
- Lorenzo Cavagna
- Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
- Ernesto Trallero-Araguás
- Department of Internal Medicine, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, Spain
- Federica Meloni
- Department of Pneumology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN Lung, 27100 Pavia, Italy
- Ilaria Cavazzana
- Department of Rheumatology, University and ASST Spedali Civili—Brescia and ERN ReCONNET, 25123 Brescia, Italy
- Jorge Rojas-Serrano
- Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico
- Eugen Feist
- Department of Rheumatology, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
- Giovanni Zanframundo
- Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
- Valentina Morandi
- Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
- Alain Meyer
- Department of Rheumatology, Hôpitaux Universitaires de Strasbourg and ERN ReCONNET, 67000 Strasbourg, France
- Jose Antonio Pereira da Silva
- Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
- Carlo Jorge Matos Costa
- Department of Rheumatology, Centro Hospitalar e Universitário de Coimbra, 3000-075 Coimbra, Portugal
- Oyvind Molberg
- Department of Rheumatology, Oslo University Hospital, 0372 Oslo, Norway
- Helena Andersson
- Department of Rheumatology, Oslo University Hospital, 0372 Oslo, Norway
- Veronica Codullo
- Department of Rheumatology, Cochin Hospital, 75014 Paris, France
- Marta Mosca
- Department of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
- Simone Barsotti
- Department of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
- Rossella Neri
- Department of Rheumatology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
- Carlo Scirè
- Department of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy
- Marcello Govoni
- Department of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy
- Federica Furini
- Department of Rheumatology, Azienda Ospedaliero Universitaria S. Anna, 44124 Ferrara, Italy
- Francisco Javier Lopez-Longo
- Department of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Julia Martinez-Barrio
- Department of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
- Udo Schneider
- Department of Rheumatology, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
- Hanns-Martin Lorenz
- Department of Rheumatology, University of Heidelberg, 69117 Heidelberg, Germany
- Andrea Doria
- Department of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, Italy
- Anna Ghirardello
- Department of Rheumatology, University of Padua and ERN ReCONNET, 35122 Padova, Italy
- Norberto Ortego-Centeno
- Department of Rheumatology, Hospital Universitario San Cecilio, 18016 Granada, Spain
- Marco Confalonieri
- Department of Pneumology, University Hospital of Cattinara, 34149 Trieste, Italy
- Paola Tomietto
- Department of Rheumatology, University Hospital of Cattinara, 34149 Trieste, Italy
- Nicolò Pipitone
- Department of Rheumatology, S. Maria Hospital—IRCCS, 42123 Reggio Emilia, Italy
- Ana Belen Rodriguez Cambron
- Department of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, Spain
- María Ángeles Blázquez Cañamero
- Department of Rheumatology, Severo Ochoa Hospital, 28911 Madrid, Spain
- Reinhard Edmund Voll
- Department of Rheumatology and Clinical Immunology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany
- Sarah Wendel
- Department of Rheumatology and Clinical Immunology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79110 Freiburg, Germany
- Salvatore Scarpato
- Department of Rheumatology, Ospedale “ Scarlato” Scafati, 84018 Scafati, Italy
- Francois Maurier
- Department of Rheumatology, HP Metz, Hopital Belle-Ile, 57000 Metz, France
- Massimiliano Limonta
- Department of Rheumatology, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy
- Paolo Colombelli
- Department of Rheumatology, Ospedale di Treviglio, 24047 Treviglio, Italy
- Margherita Giannini
- Service de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, France
- Bernard Geny
- Service de Physiologie des Explorations Fonctionnelles, NHC Strasbourg, Université de Strasbourg, 67000 Strasbourg, France
- Eugenio Arrigoni
- Department of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy
- Elena Bravi
- Department of Rheumatology, Ospedale Guglielmo da Saliceto, 29121 Piacenza, Italy
- Paola Migliorini
- Department of Immunology, Azienda Ospedaliera Universitaria Pisana, Pisa and ERN ReCONNET, 56126 Pisa, Italy
- Alessandro Mathieu
- Department of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, Italy
- Matteo Piga
- Department of Rheumatology, University Clinic and AOU of Cagliari, 09100 Cagliari, Italy
- Ulrich Drott
- Department of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany
- Christiane Delbrueck
- Department of Rheumatology, Johann Wolfgang Goethe-Universität, 60590 Frankfurt, Germany
- Jutta Bauhammer
- Department of Rheumatology, ACURA Centre for Rheumatic Diseases, 76530 Baden-Baden, Germany
- Giovanni Cagnotto
- Department of Rheumatology, Skane University Hospital, 22242 Lund, Sweden
- Carlo Vancheri
- Department of Pneumology, AOU Catania, 95100 Catania, Italy
- Gianluca Sambataro
- Department of Pneumology, AOU Catania, 95100 Catania, Italy
- Ellen De Langhe
- Department of Rheumatology, University Hospitals, 3000 Leuven, Belgium
- Pier Paolo Sainaghi
- Department of Rheumatology at CAAD, DiMet, University of Eastern Piedmont (UPO) and AOU “Maggiore della Carità”, 28100 Novara, Italy
- Cristina Monti
- Department of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, Italy
- Francesca Gigli Berzolari
- Department of Public Health, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia, Italy
- Mariaeva Romano
- Department of Rheumatology, Niguarda Hospital, 20162 Milan, Italy
- Francesco Bonella
- Department of Pneumology, Ruhrlandklinik, University of Duisburg-Essen and ERN Lung, 45239 Essen, Germany
- Christof Specker
- Department of Rheumatology, Ruhrlandklinik, University of Duisburg-Essen, 45239 Essen, Germany
- Andreas Schwarting
- Department of Rheumatology, Johannes Gutenberg-University, 55122 Mainz, Germany
- Ignacio Villa Blanco
- Department of Rheumatology, Sierrallana Hospital, 39300 Torrelavega, Spain
- Carlo Selmi
- Department of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
- Angela Ceribelli
- Department of Rheumatology, Humanitas Research Hospital, Rozzano, 20089 Milan, Italy
- Laura Nuno
- Department of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, Spain
- Antonio Mera-Varela
- Department of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, Spain
- Nair Perez Gomez
- Department of Rheumatology, Hospital Clínico Universitario de Santiago de Compostela, 15702 Santiago de Compostela, Spain
- Enrico Fusaro
- Department of Rheumatology, Città della Salute e della Scienza, 10126 Turin, Italy
- Simone Parisi
- Department of Rheumatology, Città della Salute e della Scienza, 10126 Turin, Italy
- Luigi Sinigaglia
- Department of Rheumatology, Hospital G. Pini—CTO, 20122 Milan, Italy
- Nicoletta Del Papa
- Department of Rheumatology, Hospital G. Pini—CTO, 20122 Milan, Italy
- Maurizio Benucci
- Department of Rheumatology, Azienda Ospedaliera San Giovanni di Dio, 50143 Firenze, Italy
- Marco Amedeo Cimmino
- Department of Rheumatology, University of Genova 16126 Genova, Italy
- Valeria Riccieri
- Department of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, Italy
- Fabrizio Conti
- Department of Rheumatology, University La Sapienza and Policlinico Umberto I, 00161 Rome, Italy
- Gian Domenico Sebastiani
- Department of Rheumatology, Ospedale San Camillo, 00152 Rome, Italy
- Annamaria Iuliano
- Department of Rheumatology, Ospedale San Camillo, 00152 Rome, Italy
- Giacomo Emmi
- Department of Internal Medicine, AOU Careggi, 50134 Firenze, Italy
- Daniele Cammelli
- Department of Immunology, AOU Careggi, 50134 Firenze, Italy
- Marco Sebastiani
- Department of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy
- Andreina Manfredi
- Department of Rheumatology, Azienda Ospedaliera Universitaria di Modena, 41125 Modena, Italy
- Javier Bachiller-Corral
- Department of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
- Walter Alberto Sifuentes Giraldo
- Department of Rheumatology, Hospital Universitario Ramon y Cajal, 28034 Madrid, Spain
- Giuseppe Paolazzi
- Department of Rheumatology, Ospedale Santa Chiara, 38122 Trento, Italy
- Lesley Ann Saketkoo
- University Medical Center- Comprehensive Pulmonary Hypertension Center & Interstitial Lung Disease Clinic Programs, Louisiana State University and Tulane University Schools of Medicine, Pulmonary Division New Orleans, New Orleans, LA 1542, USA
- Roberto Giorgi
- Department of Rheumatology, ASL Cuneo 2, 12051 Alba, Italy
- Fausto Salaffi
- Department of Rheumatology, Polytechnic University of Marche, C. Urbani Hospital, 60035 Jesi, Italy
- Jose Cifrian
- Department of Pneumology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain
- Roberto Caporali
- Department of Clinical Sciences and Community Health, University of Milan and Gaetano Pini Hospital, 20122 Milan, Italy
- Francesco Locatelli
- Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
- Enrico Marchioni
- Department of Neurology, IRCCS Mondino Foundation, 27100 Pavia, Italy
- Alberto Pesci
- Department of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy
- Giulia Dei
- Department of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy
- Maria Rosa Pozzi
- Department of Pneumology, Univerity of Milano Bicocca, San Gerardo Hospital, 20900 Monza, Italy
- Lomater Claudia
- Department of Rheumatology, Mauriziano Hospital, 10126 Turin, Italy
- Jorg Distler
- Department of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
- Johannes Knitza
- Department of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
- George Schett
- Department of Internal Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
- Florenzo Iannone
- Rheumatology Unit—DETO, University of Bari, 70121 Bari, Italy
- Marco Fornaro
- Rheumatology Unit—DETO, University of Bari, 70121 Bari, Italy
- Franco Franceschini
- Department of Rheumatology, University and ASST Spedali Civili—Brescia and ERN ReCONNET, 25123 Brescia, Italy
- Luca Quartuccio
- Clinic of Rheumatology, Department of Medicine, Santa Maria della Misericordia Hospital and University of Udine, 33100 Udine, Italy
- Roberto Gerli
- Rheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, Italy
- Elena Bartoloni
- Rheumatology Unit, Department of Medicine, University of Perugia, 06129 Perugia, Italy
- Silvia Bellando Randone
- Department of Rheumatology, AOU Careggi, 50134 Firenze, Italy
- Giuseppe Zampogna
- Department of Rheumatology, AO Brunico, 39031 Bruneck, Italy
- Montserrat I. Gonzalez Perez
- Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico
- Mayra Mejia
- Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosio Villegas, 14080 Mexico City, Mexico
- Esther Vicente
- Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, Spain
- Konstantinos Triantafyllias
- Department of Rheumatology, ACURA Center for Rheumatic Diseases, 55543 Bad Kreuznach, Germany
- Raquel Lopez-Mejias
- Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain
- Marco Matucci-Cerinic
- Department of Rheumatology, AOU Careggi, 50134 Firenze, Italy
- Albert Selva-O’Callaghan
- Department of Internal Medicine, Vall d’Hebron General Hospital, Universitat Autonoma de Barcelona, GEAS group, 08035 Barcelona, Spain
- Santos Castañeda
- Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, 28006 Madrid, Spain
- Carlomaurizio Montecucco
- Department of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation of Pavia and ERN ReCONNET, 27100 Pavia, Italy
- Miguel Angel Gonzalez-Gay
- Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria Santander, 39008 Santander, Spain
- DOI
- https://doi.org/10.3390/jcm8112013
- Journal volume & issue
-
Vol. 8,
no. 11
p. 2013
Abstract
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group’s cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The “ex-novo” occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies’ positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition.
Keywords