Association of Vitamin D levels with blood pressure changes and mean arterial pressure in prediabetics

Abstract

Background: Hypertension, which is associated with cardiovascular disease, is emerging as a risk factor for prediabetes and diabetes. A few studies have taken into account of the impact of Vitamin D on blood pressure (BP) in individuals who have hypertension. It is still not clear whether serum Vitamin D concentration plays an important role in causing hypertension or not. Methods: The present study was planned to study the correlation of Vitamin D with BP and changes in mean arterial in prediabetics. This case–control study was conducted in Department of Biochemistry in collaboration with Department of Endocrinology, PGIMS, Rohtak. Forty consecutive diagnosed cases of prediabetes and forty age- and sex-matched healthy normoglycemic controls were enrolled. Routine biochemistry investigations were done as per standard methods. Serum 25-hydroxy vitamin D was analyzed by radioimmunoassay. SPSS version 23 was used, and results were expressed as mean ± standard deviation. Results: Systolic as well as diastolic BP (DBP) and mean arterial BP were higher in prediabetes cases as compared to controls. Vitamin D levels showed a negative correlation with systolic BP, DBP, and mean arterial pressure (MAP) in both prediabetes cases as well as in controls. Conclusions: The findings of the present study suggest that BP changes and MAP might be causative factor in the pathogenesis of prediabetes.

Keywords

• hypertension
• insulin resistance
• metabolic syndrome
• prediabetes