The Path to an Evidence-Based Treatment Protocol for Extraoral Photobiomodulation Therapy for the Prevention of Oral Mucositis

Ather Adnan; Anna N. Yaroslavsky; Anna N. Yaroslavsky; James D. Carroll; Wayne Selting; Amy F. Juliano; Wendy B. London; Stephen T. Sonis; Stephen T. Sonis; Stephen T. Sonis; Christine N. Duncan; Nathaniel S. Treister; Nathaniel S. Treister

doi:10.3389/froh.2021.689386

Frontiers in Oral Health (Jul 2021)

The Path to an Evidence-Based Treatment Protocol for Extraoral Photobiomodulation Therapy for the Prevention of Oral Mucositis

Ather Adnan,
Anna N. Yaroslavsky,
Anna N. Yaroslavsky,
James D. Carroll,
Wayne Selting,
Amy F. Juliano,
Wendy B. London,
Stephen T. Sonis,
Stephen T. Sonis,
Stephen T. Sonis,
Christine N. Duncan,
Nathaniel S. Treister,
Nathaniel S. Treister

Affiliations

Ather Adnan: Texas A&M University Health Science Center, College of Medicine, Houston, TX, United States
Anna N. Yaroslavsky: Advanced Biophotonics Laboratory, Department of Physics and Applied Physics, University of Massachusetts Lowell, Lowell, MA, United States
Anna N. Yaroslavsky: Department of Dermatology, Massachusetts General Hospital, Boston, MA, United States
James D. Carroll: THOR Photomedicine, Chesham, United Kingdom
Wayne Selting: Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genoa, Italy
Amy F. Juliano: Department of Radiology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States
Wendy B. London: Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, United States
Stephen T. Sonis: Department of Surgery, Divisions of Oral Medicine and Dentistry, Brigham and Women's Hospital and the Dana-Farber Cancer Institute, Boston, MA, United States
Stephen T. Sonis: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States
Stephen T. Sonis: 0Biomodels LLC., Waltham, MA, United States
Christine N. Duncan: Department of Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, United States
Nathaniel S. Treister: Department of Surgery, Divisions of Oral Medicine and Dentistry, Brigham and Women's Hospital and the Dana-Farber Cancer Institute, Boston, MA, United States
Nathaniel S. Treister: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States

DOI: https://doi.org/10.3389/froh.2021.689386
Journal volume & issue: Vol. 2

Abstract

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Oral mucositis is a painful complication of hematopoietic stem cell transplantation for which photobiomodulation therapy (PBMT) is a safe and effective intervention. Extraoral delivery of PBMT has clinical advantages over intraoral delivery but requires additional dosimetric considerations due to the external tissue layers through which the light must propagate before reaching the oral mucosa. Additionally, to date there has been no dose modeling study, a task essential to developing a justified treatment protocol. We review here some of the complexities surrounding extraoral photobiomodulation therapy and offer that may help guide researchers toward an evidence-based treatment protocol for the prevention of oral mucositis.

Published in Frontiers in Oral Health

ISSN: 2673-4842 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Dentistry
Website: https://www.frontiersin.org/journals/oral-health#

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Abstract

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