Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders

Donna M. Werling; Neelroop N. Parikshak; Daniel H. Geschwind

doi:10.1038/ncomms10717

Nature Communications (Feb 2016)

Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders

Donna M. Werling,
Neelroop N. Parikshak,
Daniel H. Geschwind

Affiliations

Donna M. Werling: Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles
Neelroop N. Parikshak: Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles
Daniel H. Geschwind: Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles

DOI: https://doi.org/10.1038/ncomms10717
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Autism spectrum disorder is approximately 4.5 times more likely to occur in boys than girls. Here, Werling, Geschwind and Parikshak characterized sexually dimorphic gene expression in the non-diseased, post-mortem, adult and prenatal human brain, and show genes expressed at higher levels in males are significantly enriched for genes upregulated in autistic brain.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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