Communications Chemistry (Feb 2023)

A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes

  • Kui Zeng,
  • Ruhuai Mei,
  • Sebastian Dechert,
  • Lutz Ackermann,
  • Kai Zhang

DOI
https://doi.org/10.1038/s42004-023-00828-2
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 9

Abstract

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Indolizine-2-carbaldehydes are important precursors for indolizine synthesis, however, their efficient construction remains challenging. Here, a recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of 1,2,3-trisubstituted indolizine-2-carbaldehydes is reported, via [3+2] annulations of acyl pyridines and α,β-unsaturated aldehydes.