A Rare Benign Granular Cell Tumor in the Axillary Tail of Spence

Abstract

Granular cell tumor (GCT) is a rare Schwannian neoplasm, known to mimic carcinomas. GCT typically presents in the tongue but has also been reported at unusual sites with only 2% of cases said to be malignant. We report an unusual case of GCT presenting in the right breast of a 61-year-old female. Ultrasound-guided FNAC revealed scanty cellularity and fibroadipose tissue. Trucut biopsies revealed a combination of atypical cells and fibrocollagenous tissue. Histopathological examination of excision specimen with axillary clearance demonstrated large polygonal cells with abundant eosinophilic granular cytoplasm, peripherally placed nuclei, and pustulo-ovoid bodies of Milian. Importantly, neither mitotic activity nor pleomorphism were seen. All the lymph nodes were free of tumor. Given its rarity and diverse clinical presentation, GCT poses many diagnostic challenges. A holistic approach encompassing clinical, radiological, and histopathological assessments is paramount for accurate diagnosis and management of this neoplasm. Follow up is mandatory to monitor recurrence.

Keywords

• granular cell tumor
• breast
• benign
• neoplasm
• axillary tail