Communications Biology (Sep 2021)

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1

  • Onisha Patel,
  • Michael J. Roy,
  • Ashleigh Kropp,
  • Joshua M. Hardy,
  • Weiwen Dai,
  • Isabelle S. Lucet

DOI
https://doi.org/10.1038/s42003-021-02631-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Patel et al. report crystal structures of the kinase domain of Doublecortin-like kinase 1 (DCLK1) in complex with a potent inhibitor and its precursors. Their structural study reveals insights into the mode of action of the inhibitor DCLK1-IN-1 and sets the basis for the design of isoform-specific inhibitors of DCLK1, which plays a role in tumour growth and development.