Stability and Hopf bifurcation of an HIV infection model with two time delays

Abstract

This work focuses on an HIV infection model with intracellular delay and immune response delay, in which the former delay refers to the time it takes for healthy cells to become infectious after infection, and the latter delay refers to the time when immune cells are activated and induced by infected cells. By investigating the properties of the associated characteristic equation, we derive sufficient criteria for the asymptotic stability of the equilibria and the existence of Hopf bifurcation to the delayed model. Based on normal form theory and center manifold theorem, the stability and the direction of the Hopf bifurcating periodic solutions are studied. The results reveal that the intracellular delay cannot affect the stability of the immunity-present equilibrium, but the immune response delay can destabilize the stable immunity-present equilibrium through the Hopf bifurcation. Numerical simulations are provided to support the theoretical results.

Keywords

• hiv infection model
• intracellular delay
• immune response delay
• stability analysis
• hopf bifurcation