Research progress of fibroblast growth factor homologous factor 1 in the pathogenesis of arrhythmia

Abstract

Fibroblast growth factor homologous factor 1 (FHF1) is an intracellular signaling protein, a non-specific fibroblast growth factor that does not bind to fibroblast growth factor receptors. FHF1 combines with the C-terminus of cardiac voltage-gated sodium ion channels to regulate Na+current, which in turn affects the action potential of myocardial cells and results in arrhythmias with a higher frequence.

Keywords

• fibroblast growth factor homologous factor|arrhythmia|sodium channel|phosphorylation