MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation

Sophie Nolivos; Amy L. Upton; Anjana Badrinarayanan; Julius Müller; Katarzyna Zawadzka; Jakub Wiktor; Amber Gill; Lidia Arciszewska; Emilien Nicolas; David Sherratt

doi:10.1038/ncomms10466

Nature Communications (Jan 2016)

MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation

Sophie Nolivos,
Amy L. Upton,
Anjana Badrinarayanan,
Julius Müller,
Katarzyna Zawadzka,
Jakub Wiktor,
Amber Gill,
Lidia Arciszewska,
Emilien Nicolas,
David Sherratt

Affiliations

Sophie Nolivos: Department of Biochemistry, University of Oxford
Amy L. Upton: Department of Biochemistry, University of Oxford
Anjana Badrinarayanan: Department of Biochemistry, University of Oxford
Julius Müller: The Jenner Institute, University of Oxford
Katarzyna Zawadzka: Department of Biochemistry, University of Oxford
Jakub Wiktor: Department of Biochemistry, University of Oxford
Amber Gill: Department of Biochemistry, University of Oxford
Lidia Arciszewska: Department of Biochemistry, University of Oxford
Emilien Nicolas: Department of Biochemistry, University of Oxford
David Sherratt: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/ncomms10466
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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MukBEF, the bacterial structural maintenance of chromosomes complex, is known to associate with origins of replication and topoisomerase IV. Here the authors show an association of MukBEF with MatP and replication termination regions, important for proper sister chromatid decatenation and segregation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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