Biomolecules (May 2023)

Endotrophin Levels Are Associated with Allograft Outcomes in Kidney Transplant Recipients

  • Nadja Sparding,
  • Federica Genovese,
  • Daniel Guldager Kring Rasmussen,
  • Morten A. Karsdal,
  • Nicoline V. Krogstrup,
  • Marie Bodilsen Nielsen,
  • Mads Hornum,
  • Subagini Nagarajah,
  • Henrik Birn,
  • The CONTEXT Study Group,
  • Bente Jespersen,
  • Martin Tepel,
  • Rikke Nørregaard

DOI
https://doi.org/10.3390/biom13050792
Journal volume & issue
Vol. 13, no. 5
p. 792

Abstract

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Early prediction of kidney graft function may assist clinical management, and for this, reliable non-invasive biomarkers are needed. We evaluated endotrophin (ETP), a novel non-invasive biomarker of collagen type VI formation, as a prognostic marker in kidney transplant recipients. ETP levels were measured with the PRO-C6 ELISA in the plasma (P-ETP) of 218 and urine (U-ETP/Cr) of 172 kidney transplant recipients, one (D1) and five (D5) days, as well as three (M3) and twelve (M12) months, after transplantation. P-ETP and U-ETP/Cr at D1 (P-ETP AUC = 0.86, p p = 0.0002) were independent markers of delayed graft function (DGF) and P-ETP at D1 had an odds ratio of 6.3 (p p p = 0.007). This study suggests that ETP at D1 can identify patients at risk of delayed graft function and that U-ETP/Cr at M3 can predict the future status of the allograft. Thus, measuring collagen type VI formation could aid in predicting graft function in kidney transplant recipients.

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