Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Simona Colletta
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Emanuela Laratta
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Matteo Mellace
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Bruno Tilocca
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Carlotta Ceniti
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy
Andrea Urbani
Department of Diagnostic and Laboratory Medicine, Unity of Chemistry, Biochemistry and Clinical Molecular Biology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics Research, Catholic University of the Sacred Heart, Università Cattolica del Sacro Cuore, Rome, Italy
Paola Roncada
Department of Health Sciences, University Magna Graecia of Catanzaro, viale Europa, 88100 Catanzaro, Italy; Corresponding author.
Zoonoses have rapidly spread globally, necessitating the implementation of vaccination strategies as a control measure. Emerging and re-emerging vector-borne diseases are among the major global public health concerns. Dengue, a zoonotic viral infection transmitted to humans by a vector, the Aedes mosquito, is a severe global health problem. Dengue is a serious tropical infectious disease, second only to malaria, causing around 25,000 deaths each year. The resurgence of Dengue is mainly due to climate change, demographic transitions and evolving social dynamics. The development of an effective vaccine against Dengue has proven to be a complex undertaking due to four different viral serotypes with distinct antigenic profiles. This review highlights the urgent need to address the dengue threat by exploring the application of biotechnological and -OMICS sciences.
