Cellular Oncology (Jan 2010)

PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells

  • Mari Kaarbø,
  • Øyvind Løveseter Mikkelsen,
  • Lene Malerød,
  • Su Qu,
  • Viola H. Lobert,
  • Gulcan Akgul,
  • Thomas Halvorsen,
  • Gunhild M. Mælandsmo,
  • Fahri Saatcioglu

DOI
https://doi.org/10.3233/CLO-2009-0487
Journal volume & issue
Vol. 32, no. 1-2
pp. 11 – 27

Abstract

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Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of the most important pathways implicated in prostate cancer. Previous work has shown that there is crosstalk between these two pathways; however, there are conflicting findings and the molecular mechanisms are not clear. Here we studied the AR–PI3K pathway crosstalk in prostate cancer cells in vitro as well as in vivo.