Frontiers in Neuroscience (Aug 2023)
Alterations in static and dynamic regional homogeneity in mesial temporal lobe epilepsy with and without initial precipitating injury
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xinyue Mao,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Xiaonan Zhang,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Chengru Song,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Keran Ma,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Kefan Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Xin Wang,
- Yajun Lian,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang,
- Yan Zhang
Affiliations
- Xinyue Mao
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xinyue Mao
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xinyue Mao
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xinyue Mao
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xinyue Mao
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xinyue Mao
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Xinyue Mao
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xiaonan Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Xiaonan Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Chengru Song
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Chengru Song
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Chengru Song
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Chengru Song
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Chengru Song
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Chengru Song
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Chengru Song
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Keran Ma
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Keran Ma
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Keran Ma
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Keran Ma
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Keran Ma
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Keran Ma
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Keran Ma
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Kefan Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Kefan Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Kefan Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Kefan Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Kefan Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Kefan Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Kefan Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Xin Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xin Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Xin Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Xin Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Xin Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Xin Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Xin Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yajun Lian
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Yong Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Shaoqiang Han
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Jingliang Cheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yan Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yan Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yan Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yan Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yan Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yan Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China,
- Yan Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fnins.2023.1226077
- Journal volume & issue
-
Vol. 17
Abstract
ObjectivesInitial precipitating injury (IPI) such as febrile convulsion and intracranial infection will increase the susceptibility to epilepsy. It is still unknown if the functional deficits differ between mesial temporal lobe epilepsy with IPI (mTLE-IPI) and without IPI (mTLE-NO).MethodsWe recruited 25 mTLE-IPI patients, 35 mTLE-NO patients and 33 healthy controls (HC). Static regional homogeneity (sReHo) and dynamic regional homogeneity (dReHo) were then adopted to estimate the alterations of local neuronal activity. One-way analysis of variance was used to analyze the differences between the three groups in sReHo and dReHo. Then the results were utilized as masks for further between-group comparisons. Besides, correlation analyses were carried out to detect the potential relationships between abnormal regional homogeneity indicators and clinical characteristics.ResultsWhen compared with HC, the bilateral thalamus and the visual cortex in mTLE-IPI patients showed an increase in both sReHo and variability of dReHo. Besides, mTLE-IPI patients exhibited decreased sReHo in the right cerebellum crus1/crus2, inferior parietal lobule and temporal neocortex. mTLE-NO patients showed decreased sReHo and variability of dReHo in the bilateral temporal neocortex compared with HC. Increased sReHo and variability of dReHo were found in the bilateral visual cortex when mTLE-IPI patients was compared with mTLE-NO patients, as well as increased variability of dReHo in the left thalamus and decreased sReHo in the right dorsolateral prefrontal cortex. Additionally, we discovered a negative correlation between the national hospital seizure severity scale testing score and sReHo in the right cerebellum crus1 in mTLE-IPI patients.ConclusionAccording to the aforementioned findings, both mTLE-IPI and mTLE-NO patients had significant anomalies in local neuronal activity, although the functional deficits were much severer in mTLE-IPI patients. The use of sReHo and dReHo may provide a novel insight into the impact of the presence of IPI on the development of mTLE.
Keywords
- mesial temporal lobe epilepsy
- initial precipitating injury
- resting-state functional MRI
- regional homogeneity
- dynamic
- cognitive impairment