Complications and management in Descemet′s stripping endothelial keratoplasty: Analysis of consecutive 430 cases

Abstract

Purpose: To analyze the complications and their managements in Descemet′s stripping endothelial keratoplasty (DSEK) in consecutive 430 cases by single surgeon in a tertiary eye hospital. Materials and Methods: 430 eyes of 366 patients with endothelial dysfunctions scheduled for DSEK, were analyzed retrospectively. In all cases donor dissection was performed manually, and ′Taco′ insertion and unfolding technique was used. Intra-operative and postoperative complications with their managements and outcomes were reviewed retrospectively. Periodic endothelial cell density was analyzed for each patient till the last visit. Follow-up period was between 3 to 60 months (mean 18.7 months). Results: 13 (3.0%) eyes had operative complications during donor dissection and 16 (3.7%) had during recipient procedure. In 7 (1.6%) eyes, donor lenticule was replaced with a new one during the surgery. In early postoperative period, 21 (4.9%) eyes had donor dislocation and 12 (2.8%) eyes had air-induced pupillary block; and they were managed immediately. 2 cases had primary graft failure and in 1 case had postoperative bacterial endophthalmitis requiring evisceration. In late postoperative period, 48 (11.3%) eyes had secondary glaucoma and 14 (3.3%) eyes had late secondary graft failure. Endothelial rejection occurred in 5 (1.2%) cases. Mean endothelial cell loss was 19.7% after 3 months and 54.2% after 5 years. Total graft failure in this series was 31 (7.2%) and in 17 cases re-DSEK was performed successfully. Conclusions: Both operative and postoperative complications do occur in DSEK. Most of these complications can be managed by medical or appropriate surgical means. Some of the complications can be avoided and reduced with experience.

Keywords

• Blindness
• cataract
• eye lens
• risk factors
• treatment of cataract
• Low vision care
• multiple disabilities and visual impairment
• reading performance
• Accommodation
• presbyopia
• supraciliary segment implants
• Amblyopia
• citicoline
• patching
• Corneal endothelium
• human corneal endothelial precursor cells
• in vitro expansion
• sphere forming assay
• thermo-reversible gelation polymer
• transportation
• Endophthalmitis
• explantation
• fungal
• intraocular lens
• postoperative
• recurrent
• Colour perception
• learning disabilities
• school children
• stereo acuity
• testability
• visual acuity
• Contracted socket
• dermis fat graft
• porous orbital implant
• reconstruction
• Glucose
• in vitro anticataract
• lens
• Moringa oliefera
• ′BARC I-125 Ocu-Prosta seeds′
• choroidal melanoma
• ciliary body melanoma
• Episcleral plaque brachytherapy
• retinal angioma
• retinoblastoma
• vasoproliferative tumor
• Congenital glaucoma
• gonioscopy
• Retcam
• Acoustic features
• A-scan
• B-scan
• choroidal mass
• ultrasound biomicroscopy
• Cataract surgery
• education
• informed consent
• multimedia
• rural health
• Lagophthalmos
• silicone sling
• temporalis muscle
• Contrast sensitivity function
• disability
• function peak
• multiple sclerosis
• spatial frequency
• Congenital cataract
• developmental cataract
• outcome
• vision function
• Bacterial
• extracellular enzymes
• fungal
• keratitis
• toxins
• Exotropic Duane retraction syndrome
• periosteal fixation
• strabismus surgery
• vertical rectus transposition
• Descemet′s stripping endothelial keratoplasty
• complications
• donor dislocation
• endothelial cell loss
• graft failure
• management