Mathematical analysis of a phase-field model of brain cancers with chemotherapy and antiangiogenic therapy effects

Abstract

Our aim in this paper is to study a mathematical model for brain cancers with chemotherapy and antiangiogenic therapy effects. We prove the existence and uniqueness of biologically relevant (nonnegative) solutions. We then address the important question of optimal treatment. More precisely, we study the problem of finding the controls that provide the optimal cytotoxic and antiangiogenic effects to treat the cancer.

Keywords

• brain cancer
• chemiotherapy
• antiangiogenic therapy
• well-posedness
• optimal control