Síntese e caracterização de beads acrílicos preparados por polimerização em suspensão visando aplicação como excipiente farmacêutico para compressão direta

Abstract

One of the difficulties reported for the suspension polymerization is control the size and granulometry of beads. The purpose of this work was to evaluate the use of cellulose nanowhiskers and mesoporous silica as stabilizers to reduce the size and the particle distribution. To monitor polymerization process was used FTIR-ATR spectroscopy. The morphology was analyzed by scanning electron microscopy. The particle size distribution was characterised using a CILAS granulometer. Thermal stability was studied by thermogravimetric analysis. The results indicated that cellulose nanowhiskers may provide stabilization and increase the thermal stability of the beads in contrast to mesoporous silica.

Keywords

• suspension polymerization
• stabilizers agents
• acrylic pharmaceutical excipients