Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype

Abstract

We describe a new atypical Shiga-toxin-producing Escherichia coli (STEC) responsible for a severe episode of haemolytic–uraemic syndrome in an adult with a relapse associated with bacteraemia. This STECs train of serotype O80:H2 harboured stx2c and stx2d gene subtypes, the rare eae ɛ variant and a ColV plasmid with a conserved virulence plasmidic region involved in virulence of human and avian extraintestinal pathogenic E. coli. This atypical hybrid pathotype, which represents a new threat, is a further demonstration that STEC may be a recipient for extraintestinal virulence factors and raises again the question of antibiotic therapy during STEC infection.

Keywords

• bacteraemia
• ColV plasmid
• extraintestinal virulence factors
• haemolytic–uraemic syndrome
• Shiga toxin-producing Escherichia coli