Cohort profile: The Obesity and Disease Development Sweden (ODDS) study, a pooled cohort
Bethany Van Guelpen,
Olle Melander,
Jens Wahlström,
Nancy L Pedersen,
Karl Michaëlsson,
Ming Sun,
Ylva Trolle Lagerros,
Innocent B Mboya,
Abbas Chabok,
Linnea Hedman,
Helena Backman,
Christel Haggstrom,
Patrik K E Magnusson,
Sven Sandin,
Sölve Elmståhl,
Christian Ingvar,
Bright Nwaru,
Jerzy Leppert,
Weiyao Yin,
Josef Fritz,
Karolin Isaksson,
Marisa da Silva,
Tanja Stocks
Affiliations
Bethany Van Guelpen
Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden
Olle Melander
4 Department of Clinical Science, Lund University, Skåne University Hospital Malmö, Malmö, Sweden
Jens Wahlström
Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Nancy L Pedersen
6 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Karl Michaëlsson
professor
Ming Sun
2 Department of General Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Ylva Trolle Lagerros
Clinical Epidemiology Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
Innocent B Mboya
Department of Community Health, Institute of Public Health, Kilimanjaro Christian Medical University College, Kilimanjaro, Tanzania
Abbas Chabok
13 Center for Clinical Research, Uppsala University, Västmanland Hospital, Västerås, Sweden
Linnea Hedman
Department of Public Health and Clinical Medicine, Section of Sustainable Health, The OLIN Unit, Umeå University, Umeå, Sweden
Helena Backman
Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden
Christel Haggstrom
Uppsala Universitet, Uppsala, Sweden
Patrik K E Magnusson
researcher
Sven Sandin
2 Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Sölve Elmståhl
7 Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Christian Ingvar
Lund Melanoma Study Group, Lund University, Lund, Sweden
Bright Nwaru
1Asthma UK Centre for Applied Research, Centre for Medical Informatics, Usher Institute for Population Health Sciences, The University of Edinburgh, Edinburgh, UK
Jerzy Leppert
Center for Clinical Research, Vasteras, Faculty of Medicine, Uppsala University, Uppsala, Sweden
Weiyao Yin
1 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Josef Fritz
Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria
Karolin Isaksson
Lund Melanoma Study Group, Lund University, Lund, Sweden
Marisa da Silva
1 Department of Translational Medicine, Lund University, Malmö, Sweden
Tanja Stocks
1 Department of Translational Medicine, Lund University, Malmö, Sweden
Purpose The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort to study body mass index (BMI), waist circumference (WC) and changes in weight and WC, in relation to morbidity and mortality.Participants ODDS includes 4 295 859 individuals, 2 165 048 men and 2 130 811 women, in Swedish cohorts and national registers with information on weight assessed once (2 555 098 individuals) or more (1 740 761 individuals), in total constituting 7 733 901 weight assessments at the age of 17–103 years in 1963–2020 (recalled weight as of 1911). Information on WC is available in 152 089 men and 212 658 women, out of whom 108 795 have repeated information on WC (in total 512 273 assessments). Information on morbidity and mortality was retrieved from national registers, with follow-up until the end of 2019–2021, varying between the registers.Findings to date Among all weight assessments (of which 85% are objectively measured), the median year, age and BMI (IQR) is 1985 (1977–1994) in men and 2001 (1991–2010) in women, age 19 (18–40) years in men and 30 (26–36) years in women and BMI 22.9 (20.9–25.4) kg/m2 in men and 23.2 (21.2–26.1) kg/m2 in women. Normal weight (BMI 18.5–24.9 kg/m2) is present in 67% of assessments in men and 64% in women and obesity (BMI≥30 kg/m2) in 5% of assessments in men and 10% in women. The median (IQR) follow-up time from the first objectively measured or self-reported current weight assessment until emigration, death or end of follow-up is 31.4 (21.8–40.8) years in men and 19.6 (9.3–29.0) years in women. During follow-up, 283 244 men and 123 457 women died.Future plans The large sample size and long follow-up of the ODDS Study will provide robust results on anthropometric measures in relation to risk of common diseases and causes of deaths, and novel findings in subgroups and rarer outcomes.
