PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress

Qi Sun; Yunxia Yang; Zhongqiu Wang; Xiao Yang; Yan Gao; Yang Zhao; Wenhao Ge; Junhao Liu; Xi Xu; Wei Guan; Dan Weng; Shiming Wang; Junsong Wang; Jianfa Zhang

Redox Biology (Oct 2020)

PER1 interaction with GPX1 regulates metabolic homeostasis under oxidative stress

Qi Sun,
Yunxia Yang,
Zhongqiu Wang,
Xiao Yang,
Yan Gao,
Yang Zhao,
Wenhao Ge,
Junhao Liu,
Xi Xu,
Wei Guan,
Dan Weng,
Shiming Wang,
Junsong Wang,
Jianfa Zhang

Affiliations

Qi Sun: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China; Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Bengbu Medical College, Bengbu, 233030, China
Yunxia Yang: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Zhongqiu Wang: Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China
Xiao Yang: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Yan Gao: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Yang Zhao: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Wenhao Ge: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Junhao Liu: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Xi Xu: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Wei Guan: The Second Hospital of Nanjing, Nanjing Medical University, Nanjing, 210003, China
Dan Weng: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Shiming Wang: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Junsong Wang: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China
Jianfa Zhang: Center for Molecular Metabolism, Nanjing University of Science & Technology, Nanjing, 210094, China; Corresponding author. Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing, China.

Journal volume & issue: Vol. 37
p. 101694

Abstract

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Metabolism serves mammalian feeding and active behavior, and is controlled by circadian clock. The molecular mechanism by which clock factors regulate metabolic homeostasis under oxidative stress is unclear. Here, we have characterized that the daily oxygen consumption rhythm was deregulated in Per1 deficient mice. Per1 deficiency impaired daily mitochondrial dynamics and deregulated cellular GPx-related ROS fluctuations in the peripheral organs. We identified that PER1 enhanced GPx activity through PER1/GPX1 interaction in cytoplasm, consequently improving the oxidative phosphorylation efficiency of mitochondria. Per1 expression was specifically elevated in the fasting peripheral organs for protecting mitochondrial from oxidation stress. These observations reveal that Per1-driven mitochondrial dynamics is a critical effector mechanism for the regulation of mitochondrial function in response to oxidation stress.

Published in Redox Biology

ISSN: 2213-2317 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: http://www.journals.elsevier.com/redox-biology/

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