Alfa-2-glicoproteína rica en leucina urinaria en pacientes con apendicitis aguda (Urinary leucine-rich alpha-2-glycoprotein in patients with acute appendicitis)

Abstract

The objective of research was to determine diagnostic efficacy of urinary concentrations of leucine-rich alpha-2-glycoprotein (A2GRL) in patients with acute appendicitis. There were included patients with high suspicion of acute appendicitis (group A; cases, n = 30). In group B (controls, n = 30) were included patients with non-surgical abdominal pain who attended to Hospital Central “Dr. Urquinaona”, Maracaibo, Zulia. General characteristics, urinary concentrations of A2GRL and diagnostic efficacy of assay were evaluated. Mean age of patients in group A was 36.3 +/- 8.8 years-old and in group B was 35.8 +/- 9.6 years-old (p = ns). There were not found significant differences in sex distribution, weight and height between groups (p = ns). Urinary concentrations of A2GRL were significantly higher in group A (1543.8 +/- 762.7 ng/mL) compared with mean value in patients of group B (774.1 +/- 356.1 ng/mL; p < 0.0001). A2GRL presented a value below curve 0.81. A cut-off value of 1000 ng/mL, showed sensivity 73.3%, specificity 70.9%, positive predictive value 72.4% and negative predictive value 72.4%. It is concluded that urinary concentrations of A2GRL have a high diagnostic efficacy in patients with acute appendicitis

Keywords

• Leucine-rich alpha-2-glycoprotein