Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease
Brenda Lois Barros dos Santos,
Alda Cássia Alves da Silva,
Juliana Soares Severo,
Bruno de Sousa Barbosa,
Maisa Campêlo de Sousa,
Francisco Assis dos Santos Moreira,
Lucas Estevão de Sousa,
Heron Silva Soares,
Antônio Klingem Leite de Freitas,
Francisco Leonardo Torres-Leal,
Paulo Correia-de-Sá,
Armênio Aguiar dos Santos,
Moisés Tolentino Bento da Silva
Affiliations
Brenda Lois Barros dos Santos
Graduate Program in Pharmaceutical Sciences, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Alda Cássia Alves da Silva
Laboratory of Exercise and Gastrointestinal Tract—Department of Physical Education, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Juliana Soares Severo
Laboratory of Exercise and Gastrointestinal Tract—Department of Physical Education, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Bruno de Sousa Barbosa
Graduate Program in Pharmacology, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Maisa Campêlo de Sousa
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil
Francisco Assis dos Santos Moreira
Graduate Program in Pharmacology, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Lucas Estevão de Sousa
Laboratory of Exercise and Gastrointestinal Tract—Department of Physical Education, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Heron Silva Soares
Laboratory of Exercise and Gastrointestinal Tract—Department of Physical Education, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Antônio Klingem Leite de Freitas
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil
Francisco Leonardo Torres-Leal
Graduate Program in Pharmacology, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Paulo Correia-de-Sá
Laboratory of Pharmacology and Neurobiology, (MedInUP/RISE-Health), Department of Immuno-Physiology and Pharmacology, School of Medicine and Biomedical Science—ICBAS, University of Porto, 4050-313 Porto, Portugal
Armênio Aguiar dos Santos
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza 60430-270, CE, Brazil
Moisés Tolentino Bento da Silva
Laboratory of Exercise and Gastrointestinal Tract—Department of Physical Education, Federal University of Piaui, Teresina 64049-550, PI, Brazil
Inflammatory bowel disease (IBD) induces immunological and autonomic imbalances. Exercise is a beneficial strategy for controlling IBD symptoms. We investigated the role of exercise on gastrointestinal (GI) motility changes and autonomic parameters in rats with ileitis. Rats were divided into control, ileitis, and exercise+ileitis groups. Ileitis was induced by TNBS (40 mM, intraileally). The exercise was swimming (1 h/day/4 weeks, 5%/bw). We assessed eating behaviour and oxidative stress. Body composition was assessed by bioimpedance. Autonomic balance and ECG parameters were measured by an electrocardiogram (ECG). Gastrointestinal motility was evaluated using the phenol red technique. In terms of body composition, total body water (TBW), body mass index (BMI), and fat-free mass (FFM) were higher in the ileitis group (216.80 ± 11.44 mL; 24.09 ± 2.15 g/cm2; 287.1 ± 14.66 g) (p 2; 193 ± 42.21 g) and exercise prevented (91.33 ± 12.33 mL; 11.73 ± 0.47 g/cm2; 133.8 ± 16.82 g) (p p p p p p p p p: 0.04). The current study suggests intestinal ileitis alters GI motility and autonomic balance, and physical exercise can represent an essential non-pharmacological approach to IBD treatment.
