The article objective is identifying the main transformational processes affecting the economic security of investment activities of industrial enterprises, which are the guarantee to their long-term development and the formation of a program for the transformation of the economic security system of enterprises in order to protect investment activity from the negative impact of changes in the external and internal environment. Methodology. The research is based on analytical materials and results of the evaluation of the dynamics of world investments for 2017 and statistical information concerning direct investments from different countries of the world in Ukrainian economics. The main postulates of the institutional theory are also used to characterize institutional changes in Ukraine for detailing their impact on the economic security of the investment activity of Ukrainian industrial enterprises. Results. The research results indicate negative tendencies in the sphere of investment both for the country as a whole and for particular economic entities. This is caused by the military conflict in the East of the country and investors’ distrust to the institutional component of the functioning of the domestic economy. This situation indicates the need to introduce changes in the system of economic security of domestic enterprises. Practical implications. The authors developed the program for the transformation of the economic security system of enterprises, taking into account the actual needs for ensuring the economic security of their investment activity. Value/originality. After transformations implementation, the economic security system of enterprises receives new characteristics and allows mitigating relevant threats with different efficiency level.