Frontiers in Physiology (Dec 2021)
Prospects for the Role of Ferroptosis in Fluorosis
- Yi Zhang,
- Yi Zhang,
- Yi Zhang,
- Yi Zhang,
- Yi Zhang,
- Jialong Wu,
- Jialong Wu,
- Jialong Wu,
- Jialong Wu,
- Jialong Wu,
- Lai Jiang,
- Lai Jiang,
- Lai Jiang,
- Lai Jiang,
- Lai Jiang,
- Chenkang Lu,
- Chenkang Lu,
- Chenkang Lu,
- Chenkang Lu,
- Chenkang Lu,
- Zhengwei Huang,
- Zhengwei Huang,
- Zhengwei Huang,
- Zhengwei Huang,
- Zhengwei Huang,
- Bin Liu,
- Bin Liu,
- Bin Liu,
- Bin Liu,
- Bin Liu
Affiliations
- Yi Zhang
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Zhang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Yi Zhang
- National Center for Stomatology, Shanghai, China
- Yi Zhang
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Yi Zhang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Jialong Wu
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jialong Wu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Jialong Wu
- National Center for Stomatology, Shanghai, China
- Jialong Wu
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Jialong Wu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Lai Jiang
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Lai Jiang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Lai Jiang
- National Center for Stomatology, Shanghai, China
- Lai Jiang
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Lai Jiang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Chenkang Lu
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Chenkang Lu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Chenkang Lu
- National Center for Stomatology, Shanghai, China
- Chenkang Lu
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Chenkang Lu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Zhengwei Huang
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Zhengwei Huang
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Zhengwei Huang
- National Center for Stomatology, Shanghai, China
- Zhengwei Huang
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Zhengwei Huang
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- Bin Liu
- Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Bin Liu
- College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
- Bin Liu
- National Center for Stomatology, Shanghai, China
- Bin Liu
- National Clinical Research Center for Oral Diseases, Shanghai, China
- Bin Liu
- Shanghai Key Laboratory of Stomatology, Shanghai, China
- DOI
- https://doi.org/10.3389/fphys.2021.773055
- Journal volume & issue
-
Vol. 12
Abstract
As a strong oxidant, fluorine can induce oxidative stress resulting in cellular damage. Ferroptosis is an iron-dependent type of cell death caused by unrestricted lipid peroxidation (LPO) and subsequent plasma membrane rupture. This article indicated a relationship between fluorosis and ferroptosis. Evidence of the depletion of glutathione (GSH) and increased oxidized GSH can be found in a variety of organisms in high fluorine environments. Studies have shown that high fluoride levels can reduce the antioxidant capacity of antioxidant enzymes, while increasing the contents of reactive oxygen species (ROS) and malondialdehyde (MDA), resulting in oxidative stress and fluoride-induced oxidative stress, which are related to iron metabolism disorders. Excessive fluorine causes insufficient GSH, glutathione peroxidase (GSH-Px) inhibition, and oxidative stress, resulting in ferroptosis, which may play an important role in the occurrence and development of fluorosis.
Keywords
