Highly efficient electrocatalytic oxidation of levodopa as a Parkinson therapeutic drug based on modified screen-printed electrode
Tan Wang,
Nadhir N.A. Jafar,
Afrah Majeed Ahmed Al-Rihaymee,
Dheyaa Yahaia Alhameedi,
Fadhil A. Rasen,
Furqan S. Hashim,
Talib Kh Hussein,
Montather F. Ramadan,
Kasim Kadhim Alasedi,
Muath Suliman,
Ahmed Hussien Alawadi
Affiliations
Tan Wang
Three Gorges University, College of Basie Medical Scienees, 443002, China
Nadhir N.A. Jafar
Al-Zahraa Center for Medical and Pharmaceutical Research Sciences (ZCMRS), Al-Zahraa University for Women, Karbala, 56001, Iraq
Afrah Majeed Ahmed Al-Rihaymee
Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001, Babylon, Iraq
Dheyaa Yahaia Alhameedi
Department of Anesthesia, College of health & medical Technology, Sawa University, Almuthana, Iraq
Fadhil A. Rasen
Department of Medical Engineering, Al-Esraa University College, Baghdad, Iraq
Furqan S. Hashim
Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
Talib Kh Hussein
Al-Hadi University College, Baghdad, 10011, Iraq
Montather F. Ramadan
College of Dentistry, Al-Ayen University, Thi-Qar, Iraq
Kasim Kadhim Alasedi
Department of Medical Laboratory Techniques, Altoosi University College, Najaf, Iraq
Muath Suliman
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia; Corresponding author.
Ahmed Hussien Alawadi
College of technical engineering, the Islamic University, Najaf, Iraq; College of technical engineering, the Islamic University of Al Diwaniyah, Iraq; College of technical engineering, the Islamic University of Babylon, Iraq
The current study presents the creation of a straightforward and sensitive sensor based on ZnO/Co3O4 nanocomposite modified screen-printed electrode (ZnO/Co3O4NC/SPE) for levodopa determination. At ZnO/Co3O4NC/SPE, an oxidative peak for levodopa solution in pH 6.0 phosphate buffer solution (PBS) were seen that were both more resolved and more enhanced. Levodopa was measured using differential pulse voltammetry (DPV), which showed an excellent linear range (0.001–800.0 μM) and detection limit (0.81 nM). The presence of interference did not affect the electrochemical response of levodopa at ZnO/Co3O4NC/SPE, demonstrating high selectivity. Levodopa in a real samples have been successfully detected using the manufactured sensor.
