Кардиоваскулярная терапия и профилактика (Aug 2018)

Influence of tobacco smoking on clinical efficacy of a 1-year rehabilitation programme for myocardial infarction patients of economically active age

  • M. G. Bubnova,
  • D. M. Aronov,
  • N. K. Novikova

DOI
https://doi.org/10.15829/1728-8800-2018-4-26-33
Journal volume & issue
Vol. 17, no. 4
pp. 26 – 33

Abstract

Read online

Aim. Evaluation of the efficacy of 1-year exercise based program (EP) in coronary heart disease (CHD) patients of economically active age after acute myocardial infarction (MI), depending on smoking status.Material and methods. To the study, males included (n=338) after MI (not later than 3 weeks from the event). Four groups shaped by randomization: EP patients smokers (group 1, n=84), EP non-smokers (group 2, n=85); no EP smokers (group 3, n=85) and no EP non-smokers (group 4, n=84). All patients received standard medication treatment. The EP were added, of moderate intensity (50-60% from the load in exercise test) 3 times a week during 1 year.Results. After EP in smokers (n=41) and non-smokers (n=85) there was an increase of load duration by 30,3% (p<0,001) and by 28,4% (p<0,001), and its intensity by 31,2% (p<0,001) and 30,8% (p<0,001), with 3,8% (p<0,01) increase of economicity of physical work, but only in smokers. With no EP only in non-smokers there was slight increase of exercise duration by 10,1% (p<0,01) and its intensity by 11,1% (p<0,05), but milder, and in smokers, in contrary, the economicity parameter declined by 13,3% (p<0,05). This was linked with the heart size enlargement and the left ventricle ejection fraction increase in smokers and non-smokers; in the absence of EP there were no changes, just slight (by 1,9%) (p<0,05) increase of the left ventricle ejection fraction in non-smokers. Only at EP, with similar grade in smokers and non-smokers there was decrease of atherogenic lipids levels and high density cholesterol increase. In 1 year of EP, all cases of cardiovascular adverse events significantly decreased in smokers by 44,8% (р<0,05) and in nonsmokers by 50,9% (р<0,05).Conclusion. Long term (1 year) EP of moderate intensity, in both smokers and non-smokers MI patients lead to stable disease course, decrease the rate of cardiovascuar complications and improve patients life quality. However the “smoking factor” decreases rehabilitational potentional of patient and interferes with better results achievement in cardiorehabilitation.

Keywords