Serum Catestatin Levels in Pre-eclampsia and Normotensive Pregnancy

Abstract

Background: Hypertensive disorder of pregnancy is a potentially grave threat to maternal and infant health. The aetiopathogenesis of pre-eclampsia has been proposed using several theories. Endogenously produced catestatin is a novel regulator of cardiac function and blood pressure with a possible role in understanding the disease. Aim: The aim of the study was to compare serum catestatin levels in pregnancy complicated by preeclampsia and normotensive pregnant women. Methodology: The study was an analytical cross-sectional study amongst 50 women with preeclampsia and 50 normotensive pregnant women. The two groups were matched for maternal age, body mass index and gestational age. Their blood samples were analysed for catestatin level using enzyme-linked immunosorbent assay. Results: The mean serum catestatin in pre-eclamptic participants was 3.9 ± 1.9 ng/ml and that of the normotensive arm was 3.3 ± 1.9 ng/ml (P = 0.102). Conclusion: The mean catestatin level amongst normotensive pregnant women and those with preeclampsia showed no significant difference.

Keywords

• catestatin
• hypertension
• normotensive
• preeclampsia
• pregnancy