Association between markers of inflammation and indicators of systemic endotoxemia in endogenous psychosis

Abstract

Introduction The clinical and biological studies indicate the involvement of inflammation in the pathogenesis of endogenous mental disorders. The inflammation markers leukocyte elastase, α1-proteinase inhibitor, and autoantibodies to neuroantigens reflect the severity of the pathological process in the brain. Systemic endotoxemia is a pathological process caused by an excess of endotoxins in the systemic circulation, can be considered as one of the components of the inflammatory process in endogenous psychosis. Objectives To evaluate the association between systemic inflammation markers and indicators of systemic endotoxemia in patients with endogenous psychosis. Methods The study included 25 patients aged 23-49 with endogenous psychoses (F20, F25) and 25 healthy people. The severity of symptoms was assessed using PANSS. We detected the activity of leukocyte elastase and a1-proteinase inhibitor, antibodies to neuroantigens, endotoxin (ET) concentration, and antibodies to endotoxin (aEТ) in serum. Results In 24% of cases, an increase of inflammation markers activity, ET concentration, and aET deficiency were observed (p0.05) but associated with different levels of aET, which is likely to be a consequence of previous endotoxin aggression. There were correlations between ET concentration and antibodies to neuroantigens S-100B and MBP. We also revealed the association between the activity of the inflammatory marker with the severity of clinical symptoms in patients. Conclusions Results suggest the relationship between systemic inflammation markers and indicators of systemic endotoxemia and their involvement in the pathogenesis of endogenous psychosis. Disclosure No significant relationships.

Keywords

• endogenous psychosis
• systemic inflammation
• systemic endotoxemia
• antiendotoxin antibodies