LIPID PEROXIDATION AND THE LEVEL OF FREE FATTY ACIDS IN PATIENTS WITH DIABETES 2ND TYPE IN INSULIN THERAPY AND INTENSIVE GLYCEMIC CONTROL IN ACUTE PHASE OF MYOCARDIAL INFARCTION

Abstract

Aim. To compare the efficacy of infusion and traditional pharmacological correction of carbohydrate metabolism in acute period of myocardial infarction (MI) in patients with diabetes 2nd type (DM2), to assess the intensiveness of oxidative stress and free fatty acids level in the groups of patients included. Material and methods. Totally 92 patients included with MI, of those 52 with DM2. Anamnesis of DM2 and glycemia level >10 mmol/L were randomized into I group (n=26) with intravenous infusion insulin therapy (IIT) and intensive glycemia control (IGC) by the protocol developed. Into II group we randomized 26 patients with traditional DM2 therapy that could include insulin too. IIT protocol in MI in DM2 patients was aimed to reach the exact glycemia level during exact time period with intravenous insulin load. During the 1st day target values of glucose were 10-7,8 mmol/L, for 2nd and 3rd days <8,3 mmol/L, from 4th day the standard criteria of the disease compensation were used. Results. Comparison of IIT and traditional approach effectiveness showed that IIT makes better the in-hospital clinical outcomes at earlier stages of MI in DM2.

Keywords

• diabetes mellitus 2 type
• myocardial infarction
• lipid peroxydation