SWCNTs functionalized with gold nanoradiosensitizers as radiosensitizers for enhanced radiotherapy in breast cancer

Abstract

Breast cancer is the most common and significant threat affecting women globally. Traditional methods have been widely used in cancer treatment for many years. However, the unavoidable side effects of these approaches are undeniable. Nanotechnology Through combination therapy offers the potential to improve traditional cancer treatments by reducing side effects and enhancing efficacy. In this project, we examined the potential of single-walled carbon nanotubes (SWCNTs) as advanced delivery systems for chemotherapy agents directly to tumors, as well as their role as platforms for the development of radiation sensitizers to enhance the efficacy of radiation therapy without drugs and combination therapy with chemotherapy. To confirm the successful formation of the nanoparticles, we conducted various techniques such as Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR), UV–visible spectroscopy, and X-ray diffraction (XRD) to ensure accurate verification. To evaluate the cytotoxicity of SWCNTs -Au-CUR nanoparticles, we performed MTT and hemolysis assays. Subsequently, we assessed the effectiveness of the synthesized nanoparticles against cancer cells at different concentrations, with and without the aid of X-ray. Observed results showed the correct creation and high efficacy of these nanoparticles on cancerous cells. It also showed that the presence of X-rays amplified nanoparticle toxicity, increased the ROS levels in the cancerous cells, and resulted in more effective induction of DNA damage.

Keywords

• Breast cancer
• Chemotherapy
• Radiation sensitizers
• Single-wall carbon nanotubes
• Curcumin