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CoCoMac 2.0 and the future of tract-tracing databases

Frontiers in Neuroinformatics. 2012;6 DOI 10.3389/fninf.2012.00030


Journal Homepage

Journal Title: Frontiers in Neuroinformatics

ISSN: 1662-5196 (Online)

Publisher: Frontiers Media S.A.

LCC Subject Category: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry

Country of publisher: Switzerland

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML



Rembrandt eBakker (Research Center Juelich)

Rembrandt eBakker (Ludwig-Maximilians-Universität München)

Rembrandt eBakker (Radboud University Nijmegen)

Thomas eWachtler (Ludwig-Maximilians-Universität München)

Markus eDiesmann (Research Center Juelich)

Markus eDiesmann (RWTH Aachen University)

Markus eDiesmann (RIKEN Brain Science Institute)


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 14 weeks


Abstract | Full Text

The CoCoMac database contains the results of published axonal tract-tracing studies in the macaque brain. The combined data are used to construct the macaque macro-connectome. We discuss the redevelopment of CoCoMac and compare it to six connectome-related projects: two resources that provide online access to raw tracing data in rodents, a connectome viewer for advanced 3d graphics, a partial but highly detailed rat connectome, a brain data management system that generates custom connectivity matrices, and a software package that covers the complete pipeline from connectivity data to large scale brain simulations.The 2nd edition of CoCoMac features many enhancements over the original. For example, a search wizard is provided for full access to all tables. Connectivity matrices are computed on demand in a user selected nomenclature. An online data entry system is available as a preview, and is to become a generic solution for community-driven manual data entry.We end with the question whether tract-tracing will remain the gold standard to uncover the wiring of brains, thereby mentioning developments in human connectome construction, tracer substances, polarized light imaging and serial block face scanning electron microscopy.