The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

Mara De Marco Zompit; Mònica Torres Esteban; Clémence Mooser; Salomé Adam; Silvia Emma Rossi; Alain Jeanrenaud; Pia-Amata Leimbacher; Daniel Fink; Ann-Marie K. Shorrocks; Andrew N. Blackford; Daniel Durocher; Manuel Stucki

doi:10.1038/s41467-022-31865-5

Nature Communications (Jul 2022)

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis

Mara De Marco Zompit,
Mònica Torres Esteban,
Clémence Mooser,
Salomé Adam,
Silvia Emma Rossi,
Alain Jeanrenaud,
Pia-Amata Leimbacher,
Daniel Fink,
Ann-Marie K. Shorrocks,
Andrew N. Blackford,
Daniel Durocher,
Manuel Stucki

Affiliations

Mara De Marco Zompit: Department of Gynecology, University of Zurich and University Hospital Zurich
Mònica Torres Esteban: Department of Gynecology, University of Zurich and University Hospital Zurich
Clémence Mooser: Department of Gynecology, University of Zurich and University Hospital Zurich
Salomé Adam: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Silvia Emma Rossi: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Alain Jeanrenaud: Department of Gynecology, University of Zurich and University Hospital Zurich
Pia-Amata Leimbacher: Department of Gynecology, University of Zurich and University Hospital Zurich
Daniel Fink: Department of Gynecology, University of Zurich and University Hospital Zurich
Ann-Marie K. Shorrocks: Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Andrew N. Blackford: Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
Daniel Durocher: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Manuel Stucki: Department of Gynecology, University of Zurich and University Hospital Zurich

DOI: https://doi.org/10.1038/s41467-022-31865-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal