Nature Communications (Jul 2019)
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors
- Joe M. Segal,
- Deniz Kent,
- Daniel J. Wesche,
- Soon Seng Ng,
- Maria Serra,
- Bénédicte Oulès,
- Gozde Kar,
- Guy Emerton,
- Samuel J. I. Blackford,
- Spyros Darmanis,
- Rosa Miquel,
- Tu Vinh Luong,
- Ryo Yamamoto,
- Andrew Bonham,
- Wayel Jassem,
- Nigel Heaton,
- Alessandra Vigilante,
- Aileen King,
- Rocio Sancho,
- Sarah Teichmann,
- Stephen R. Quake,
- Hiromitsu Nakauchi,
- S. Tamir Rashid
Affiliations
- Joe M. Segal
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Deniz Kent
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Daniel J. Wesche
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Soon Seng Ng
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Maria Serra
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Bénédicte Oulès
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Gozde Kar
- Wellcome Trust Sanger Institute
- Guy Emerton
- Wellcome Trust Sanger Institute
- Samuel J. I. Blackford
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Spyros Darmanis
- School of Engineering, Stanford University
- Rosa Miquel
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Tu Vinh Luong
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Ryo Yamamoto
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Andrew Bonham
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Wayel Jassem
- Institute of Liver Studies, Kings College Hospital
- Nigel Heaton
- Institute of Liver Studies, Kings College Hospital
- Alessandra Vigilante
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Aileen King
- Department of Diabetes, King’s College London
- Rocio Sancho
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- Sarah Teichmann
- Wellcome Trust Sanger Institute
- Stephen R. Quake
- School of Engineering, Stanford University
- Hiromitsu Nakauchi
- Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- S. Tamir Rashid
- Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King’s College London
- DOI
- https://doi.org/10.1038/s41467-019-11266-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of cells, which have a similar gene signature to mouse oval cells.
