Nature Communications (Nov 2020)

Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides

  • Tingzhi Lin,
  • Yuanyun Gu,
  • Pengcheng Qian,
  • Haixing Guan,
  • Patrick J. Walsh,
  • Jianyou Mao

DOI
https://doi.org/10.1038/s41467-020-19194-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Homoenolates and their higher homologs have much potential, albeit largely unrealized, in transition metal catalysis. Here, the authors report the nickel-catalyzed generation of homoenolates, and their higher homologs, via decarbonylation of cyclic anhydrides, which then undergo cross-coupling with alkyl bromides.