Nature Communications (Nov 2020)
Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides
Abstract
Homoenolates and their higher homologs have much potential, albeit largely unrealized, in transition metal catalysis. Here, the authors report the nickel-catalyzed generation of homoenolates, and their higher homologs, via decarbonylation of cyclic anhydrides, which then undergo cross-coupling with alkyl bromides.