Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

María Magallón; Sara Pastor; Ana Esther Carrión; Lucía Bañuls; Daniel Pellicer; Silvia Castillo; Sergio Bondía; María Mercedes Navarro-García; Cruz González; Francisco Dasí

doi:10.3390/jcm10061268

Journal of Clinical Medicine (Mar 2021)

Oxidative Stress and Endoplasmic Reticulum Stress in Rare Respiratory Diseases

María Magallón,
Sara Pastor,
Ana Esther Carrión,
Lucía Bañuls,
Daniel Pellicer,
Silvia Castillo,
Sergio Bondía,
María Mercedes Navarro-García,
Cruz González,
Francisco Dasí

Affiliations

María Magallón: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain
Sara Pastor: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain
Ana Esther Carrión: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain
Lucía Bañuls: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain
Daniel Pellicer: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain
Silvia Castillo: Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain
Sergio Bondía: Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain
María Mercedes Navarro-García: Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain
Cruz González: Research Group on Rare Respiratory Diseases (ERR), Instituto de Investigación Sanitaria INCLIVA, Fundación Investigación Hospital Clínico Valencia, Avda. Menéndez y Pelayo, 4, 46010 Valencia, Spain
Francisco Dasí: Research Group on Rare Respiratory Diseases (ERR), Department of Physiology, School of Medicine, University of Valencia, Avda. Blasco Ibáñez, 15, 46010 Valencia, Spain

DOI: https://doi.org/10.3390/jcm10061268
Journal volume & issue: Vol. 10, no. 6
p. 1268

Abstract

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Several studies have shown that some rare respiratory diseases, such as alpha-1 antitrypsin deficiency (AATD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), and primary ciliary dyskinesia (PCD) present oxidative stress (OS) and endoplasmic reticulum (ER) stress. Their involvement in these pathologies and the use of antioxidants as therapeutic agents to minimize the effects of OS are discussed in this review.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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Abstract

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