Cell Transplantation (Jan 2006)
Towards the Development of a Pediatric Ventricular Assist Device
- Harvey S. Borovetz P.HD,
- Stephen Badylak,
- J. Robert Boston,
- Carl Johnson,
- Robert Kormos,
- Marina V. Kameneva,
- Marwan Simaan,
- Trevor A. Snyder,
- Hiro Tsukui,
- William R. Wagner,
- Joshua Woolley,
- James Antaki,
- Chenguang Diao,
- Stijn Vandenberghe,
- Bradley Keller,
- Victor Morell,
- Peter Wearden,
- Steven Webber,
- Jeff Gardiner,
- Chung M. Li,
- Dave Paden,
- Bradley Paden,
- Shaun Snyder,
- Jingchun Wu,
- Gill Bearnson,
- John A. Hawkins,
- Gordon Jacobs,
- John Kirk,
- Pratap Khanwilkar,
- Peter C. Kouretas,
- James Long,
- R. E. Shaddy
Affiliations
- Harvey S. Borovetz P.HD
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Stephen Badylak
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- J. Robert Boston
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Carl Johnson
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Robert Kormos
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Marina V. Kameneva
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Marwan Simaan
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Trevor A. Snyder
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Hiro Tsukui
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- William R. Wagner
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- Joshua Woolley
- Department of Bioengineering McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
- James Antaki
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Chenguang Diao
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Stijn Vandenberghe
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Bradley Keller
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Victor Morell
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Peter Wearden
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Steven Webber
- Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
- Jeff Gardiner
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Chung M. Li
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Dave Paden
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Bradley Paden
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Shaun Snyder
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Jingchun Wu
- Children's Hospital of Pittsburgh, Pittsburgh, PA 15261, USA
- Gill Bearnson
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- John A. Hawkins
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- Gordon Jacobs
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- John Kirk
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- Pratap Khanwilkar
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- Peter C. Kouretas
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- James Long
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- R. E. Shaddy
- LaunchPoint Technologies Inc., Goleta, CA 93117, USA
- DOI
- https://doi.org/10.3727/000000006783982304
- Journal volume & issue
-
Vol. 15
Abstract
The very limited options available to treat ventricular failure in children with congenital and acquired heart diseases have motivated the development of a pediatric ventricular assist device at the University of Pittsburgh (UoP) and University of Pittsburgh Medical Center (UPMC). Our effort involves a consortium consisting of UoP, Children's Hospital of Pittsburgh (CHP), Carnegie Mellon University, World Heart Corporation, and LaunchPoint Technologies, Inc. The overall aim of our program is to develop a highly reliable, biocompatible ventricular assist device (VAD) for chronic support (6 months) of the unique and high-risk population of children between 3 and 15 kg (patients from birth to 2 years of age). The innovative pediatric ventricular assist device we are developing is based on a miniature mixed flow turbodynamic pump featuring magnetic levitation, to assure minimal blood trauma and risk of thrombosis. This review article discusses the limitations of current pediatric cardiac assist treatment options and the work to date by our consortium toward the development of a pediatric VAD.
