Cell-cycle arrest biomarkers in urine to predict acute kidney injury in septic and non-septic critically ill patients

Abstract

Abstract Purpose To analyse the usefulness of the composite index of the tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) as urinary biomarkers for the early prediction of AKI in septic and non-septic patients. Methods This is a prospective, observational study including patients admitted to ICU from acute care departments and hospital length of stay 0.8 predicted a rate of AKI of 71% and AKIN ≥ 2 of 62.9%. Conclusions In our study, urinary [TIMP-2]·[IGFBP7] was an early predictor of AKI in ICU patients regardless of sepsis. Besides, index values <0.8(ng/mL)2/1000 ruled out the need for renal replacement.

Keywords

• Acute kidney injury
• Biomarkers
• Tissue inhibitor of metalloproteinases-2
• Insulin-like growth factor-binding protein 7
• ICU patients
• Sepsis