Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan;, Email: [email protected]
Kenichi Ishibashi
Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan
Gone Yi Thaw Maung
The Amgen Scholar (http://amgenscholars.com/university/kyoto-university) from Department of Chemistry, University of Mandalay University Drive, 73rd Street, Mandalay, Myanmar
Yuudai Morota
Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan
Tomomi Umemura
Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan
Yumi Kato
Department of Material Chemistry Graduate School of Engineering Kyoto University Kyotodaigaku-Katsura, Nishikyo, Kyoto 615-8510, Japan
Metal-catalyzed H/D exchange in hydrothermal deuterium oxide, performed in an autoclave using external heating or in a sealed glass tube under microwave irradiation, was shown to be an efficient method for preparing various deuterium-labeled compounds. Phosphonium salts for the Wittig reaction were deuterated at the ?-position in the presence of MS 4A under microwave irradiation; primary alcohols and primary/secondary amines were deuterated at the ?-position in the presence of ruthenium catalyst under microwave irradiation; metal-catalyzed direct C–H functionalizations on sp3 and sp2 carbon gave the corresponding fully deuterated products under hydrothermal conditions. These methods gave various deuterium-labelled compounds efficiently using D2O as a D-atom source.
