Posttranslational chemical installation of azoles into translated peptides

Haruka Tsutsumi; Tomohiro Kuroda; Hiroyuki Kimura; Yuki Goto; Hiroaki Suga

doi:10.1038/s41467-021-20992-0

Nature Communications (Jan 2021)

Posttranslational chemical installation of azoles into translated peptides

Haruka Tsutsumi,
Tomohiro Kuroda,
Hiroyuki Kimura,
Yuki Goto,
Hiroaki Suga

Affiliations

Haruka Tsutsumi: Department of Chemistry, Graduate School of Science, The University of Tokyo
Tomohiro Kuroda: Department of Chemistry, Graduate School of Science, The University of Tokyo
Hiroyuki Kimura: Department of Chemistry, Graduate School of Science, The University of Tokyo
Yuki Goto: Department of Chemistry, Graduate School of Science, The University of Tokyo
Hiroaki Suga: Department of Chemistry, Graduate School of Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-021-20992-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Azoles are five-membered heterocycles found in peptidic natural products and synthetic peptiodomimetics. Here the authors demonstrate a posttranslational chemical modification method for in vitro ribosomal synthesis of peptides with exotic azole groups at specific positions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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