Depletion of VAX2 restrains the malignant progression of papillary thyroid carcinoma by modulating ERK signaling pathway

Guo Bei; Zhang Yi; Yuan Kun; Jiang Feng-Xia; Cui Qian-Bo; Zhou Qin; Dong Hong-Xia; Chen Wei; Yang Shun-Shi

doi:10.1515/biol-2019-0027

Open Life Sciences (Jul 2019)

Depletion of VAX2 restrains the malignant progression of papillary thyroid carcinoma by modulating ERK signaling pathway

Guo Bei,
Zhang Yi,
Yuan Kun,
Jiang Feng-Xia,
Cui Qian-Bo,
Zhou Qin,
Dong Hong-Xia,
Chen Wei,
Yang Shun-Shi

Affiliations

Guo Bei: Department of Otorlaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Zhang Yi: Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Yuan Kun: Department of Otorlaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Jiang Feng-Xia: Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Cui Qian-Bo: Department of Otorlaryngology Head and Neck Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Zhou Qin: Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Dong Hong-Xia: Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Chen Wei: Department of Otorlaryngology Head and Neck Surgery, The Central Hospital of Wuhan, NO.26 Shengli street, Jiangan district, Wuhan, Hubei 430014, P.R. China
Yang Shun-Shi: Department of Ultrasound, The Central Hospital of Wuhan, NO.26 Shengli street, Jiangan district, Wuhan, Hubei 430014, P.R. China

DOI: https://doi.org/10.1515/biol-2019-0027
Journal volume & issue: Vol. 14, no. 1
pp. 237 – 245

Abstract

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Ventral anterior homeobox 2 (VAX2) gene is a key regulating factor for the development of the ventral region of the eye, and has recently attracted much attention from the cancer treatment field. Our study aimed to explore the effect of VAX2 on papillary thyroid carcinoma (PTC).

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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