Peculiarities of polymorphism of <i>Helicobacter pylori</i> virulence genes and IL-1 genes in peptic ulcer of stomach and duodenum, associated with <i>Helicobacter pylori</i>

Abstract

The prevalence of H.pylori virulence genes (iceA, cagA, babA2, vacA) as well as the distribution of the IL-1 genes was studied in patients with H.pylori-associated gastric and duodenal ulcer disease. VacA s1/m2 iceA1 cagA+ и vacA s1/m2 iceA1 cagA+ babA2 genotypes of H. pylori were shown to be prevalent in the clinic isolates. Four patients were found to be infected with Ureaplasma urealyticum. The combination of the IL‑1B ‑511*Т / IL‑1B +3954*C / IL-1RN*2 alleles was shown to be prevalent among the patients with gastric and duodenal ulcer disease. The correlation between the H. pylori genotypes, the IL-1 genes and the peculiarities of ulcer disease was not found.

Keywords

• helicobacter pylori virulence factors
• il-1 cytokines
• genotyping
• ulcer disease
• persistence
• ureaplasma urealyticum