Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

Abstract

Three series of heteroaromatic analogs (twenty seven compounds) with monoketone linkers have been synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)piperidin-4-one 5e showed best antifungal activity against Aspergillus niger and Aspergillus fumigatus. Structural elucidation of the synthesized compounds was determined on the basis of various spectroscopic methods.

Keywords

• N-arylsulfonyl-3,5-diarylidene-4-piperidone
• N-alkylcarbonyl-3,5-di-arylidene-4-piperidone
• crotonisation
• antimicrobial activity